Novel Biodegradable Antimicrobial Composite Scaffold by Coating Type I Collagen Scaffold with Pepsin-Degraded SIS Extraction


作者:本站编辑    发布日期:2021-03-10

作者:

Risheng Zhong, Xin Chen,Yao Dai, Leilei Xia, Fumin Men, Bo Zhao, Yi Chen, Hairong Liu, Zheng Zhou

 

英文摘要:

Abstract:

The antimicrobial activity of tissue engineering scaffolds is crucial for successful implantations and surgeries by reducing surgical infections. In this study, small intestinal submucosa (SIS) extracts were prepared by in vitro pepsin digestion (pSIS) and its antimicrobial active is stronger than those prepared by accelerated hydrolysis (aSIS). Compared with aSIS, the average molecular weight of pSIS seems smaller with more narrow distribution via SDS-PAGE electrophoresis combined with commassie blue staining. Furthermore, pSIS coated porous type I collagen scaffold (pSIS/COL I scaffolds) displayed a strong antibacterial activity and is suitable for cell seeded and growth, indicating that it can be potentially applied to tissue engineering or surgical tissue repairing in the future.

 

关键词:

Keywords

Porcine Small Intestinal Submucosa, Acellular Matrix, Transforming Growth Factor, Basic Fibroblast Growth Factor, Vascular Endothelial Growth Factor

 

IOP Conf. Ser.: Mater. Sci. Eng., 2019, 612-022077

010-61252660

北京博辉瑞进生物科技有限公司

地址:北京市大兴区中关村科技园区大兴生物医药产业基地永大路29号

官网:http://www.biosishealing.com

电话: 010-61252660

邮箱:info@biosishealing.com

版权所有北京博辉瑞进生物科技有限公司 京ICP备16026579号 (京)-非经营性-2017-0030 京公网安备 11011502006176号 (京)网药械信息备字(2022)第00096号