德国专利:一种动物源性植入性医用生物材料的制备方法


作者:本站编辑    发布日期:2021-03-10

专利号 DE112013007127T5

专利名称

Preparation method for implantable medical biological materials of animal origin

一种动物源性植入性医用生物材料的制备方法

发明人

赵博 王振军

摘要

The present invention provides a preparation method for implantable medical biological material of animal origin comprising the following procedures: Pre-processing, and washing of animal tissue materials; inactivation of virus; decellularizing cell; sodium chloride processing; molding and packaging sterilization. Cell-free ECM materials of animal origin produced by this method can achieve the goal of completely removing cell components of animal origin and composition of DNA, and at the same time, the natural ECM composition, three-dimensional structure and active growth factor which can induce and promote tissue regeneration retain. By using this process, endotoxin, organic solvents and toxic solvent residue are thus omitted and products with different sizes, thickness and mechanical strength can be formed.

一种动物源性植入性医用生物材料的制备方法,它包括以下操作步骤:动物组织材料的前置处理与初洗;病毒灭活脱细胞;氯化钠处理;成型;包装灭菌。用该方法制备的动物源性脱细胞ECM材料完全去除了动物源细胞成分和DNA成分,同时完整的保留了天然ECM的成分、三维结构和能够诱导促进组织再生的活性生长因子,无内毒素、有机溶剂和有毒溶剂残留,并可根据不同的适应症形成具有不同尺寸、厚度和力强度的产品



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